Healthy and Sharp
One of the sources to be so healthy is Resveratrol, yes that stuff in your wine, but more of it without the alcohol in the wine.
Calorie restriction-like effects of 30 days of Resveratrol (resVidaTM) supplementation on energy metabolism and metabolic profile in obese humans
Silvie Timmers#a,b, Ellen Konings#b, Lena Biletb, Riekelt H. Houtkoopere, Tineke van de Weijerb, Gijs H. Goossensb, Joris Hoeksb, Sophie van der Kriekenb, Dongryeol Ryue, Sander Kerstenf, Esther Moonen-Kornipsb, Matthijs K.C. Hesselinkc, Iris Kunzg, Vera B. Schrauwen-Hinderlingd, Ellen Blaakb, Johan Auwerxe, and Patrick Schrauwen.
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-blind cross- over study for 30 days. Resveratrol significantly reduced sleeping- and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels, and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.